| RRC ID |
48867
|
| Author |
Zhang S, Pan C, Lv X, Wu W, Chen H, Wu W, Wu H, Zhang L, Zhao Y.
|
| Title |
Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis.
|
| Journal |
Sci Rep
|
| Abstract |
Hox genes play a fundamental role in regulating animal development. However, less is known about their functions on homeostasis maintenance in adult stem cells. Here, we report that the repression of an important axial Hox gene, Abdominal-B (Abd-B), in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an excessive expansion of early stage somatic cells, which originate from both lineages. We further demonstrate that canonical Polycomb (Pc) and functional pathway of Polycomb group (PcG) proteins are responsible for maintaining the germline cell identity non-autonomously via repressing Abd-B in CySCs in the adult Drosophila testis.
|
| Volume |
7(1)
|
| Pages |
5101
|
| Published |
2017-7-11
|
| DOI |
10.1038/s41598-017-05359-0
|
| PII |
10.1038/s41598-017-05359-0
|
| PMID |
28698559
|
| PMC |
PMC5506049
|
| MeSH |
Animals
Cell Lineage
Cells, Cultured
Drosophila / cytology*
Drosophila / genetics
Drosophila / metabolism
Drosophila Proteins / genetics*
Drosophila Proteins / metabolism*
Histones / metabolism
Homeodomain Proteins / genetics*
Homeodomain Proteins / metabolism*
Male
Polycomb Repressive Complex 1 / genetics
Polycomb Repressive Complex 1 / metabolism*
Polycomb-Group Proteins / metabolism
Spermatozoa / cytology
Spermatozoa / metabolism
Stem Cells / cytology
Stem Cells / metabolism
Testis / cytology*
Testis / metabolism
|
| IF |
3.998
|
| Times Cited |
2
|
|
WOS Category
|
CELL BIOLOGY
|
| Resource |
| Drosophila |
32443R-4
32443R-1
5595R-1 |
