論文 - 詳細
| RRC ID | 4954 |
|---|---|
| 著者 | Bi H, Sun L, Fukamachi T, Saito H, Kobayashi H. |
| タイトル | HU participates in expression of a specific set of genes required for growth and survival at acidic pH in Escherichia coli. |
| ジャーナル | Curr Microbiol |
| Abstract |
The major histone-like Escherichia coli protein, HU, is composed of alpha and beta subunits respectively encoded by hupA and hupB in Escherichia coli. A mutant deficient in both hupA and hupB grew at a slightly slower rate than the wild type at pH 7.5. Growth of the mutant diminished with a decrease in pH, and no growth was observed at pH 4.6. Mutants of either hupA or hupB grew at all pH levels tested. The arginine-dependent survival at pH 2.5 was diminished approximately 60-fold by the deletion of both hupA and hupB, whereas the survival was slightly affected by the deletion of either hupA or hupB. The mRNA levels of adiA and adiC, which respectively encode arginine decarboxylase and arginine/agmatine antiporter, were low in the mutant deficient in both hupA and hupB. The deletion of both hupA and hupB had little effect on survival at pH 2.5 in the presence of glutamate or lysine, and expression of the genes for glutamate and lysine decarboxylases was not impaired by the deletion of the HU genes. These results suggest that HU regulates expression of the specific set of genes required for growth and survival in acidic environments. |
| 巻・号 | 58(5) |
| ページ | 443-8 |
| 公開日 | 2009-5-1 |
| DOI | 10.1007/s00284-008-9340-4 |
| PMID | 19127382 |
| MeSH | Acids / pharmacology* Amino Acid Transport Systems / biosynthesis Anti-Bacterial Agents / pharmacology* Antiporters / biosynthesis Carboxy-Lyases / biosynthesis Carrier Proteins / genetics Carrier Proteins / physiology* DNA-Binding Proteins Escherichia coli / drug effects Escherichia coli / physiology* Escherichia coli Proteins / biosynthesis Escherichia coli Proteins / genetics Escherichia coli Proteins / physiology* Gene Deletion Gene Expression Profiling Glutamic Acid / metabolism Lysine / metabolism Microbial Viability* Stress, Physiological Transcription Factors / genetics Transcription Factors / physiology* |
| IF | 1.746 |
| 引用数 | 17 |
| WOS 分野 | MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(大腸菌) | ME9062(BW25113) JW0474 JW1517 JW3480 |