RRC ID 49705
著者 Yoshimatsu T, D'Orazi FD, Gamlin CR, Suzuki SC, Suli A, Kimelman D, Raible DW, Wong RO.
タイトル Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo.
ジャーナル Nat Commun
Abstract Whether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their connectivity upon regeneration of their major input. H3 horizontal cells (HCs) normally avoid red and green cones, and prefer ultraviolet over blue cones. Upon ablation of the major (ultraviolet) input, H3 HCs do not immediately increase connectivity with other cone types. Instead, H3 dendrites retract and re-extend to contact new ultraviolet cones. But, if regeneration is delayed or absent, blue-cone synaptogenesis increases and ectopic synapses are made with red and green cones. Thus, cues directing synapse specificity can be maintained following input loss, but only within a limited time period. Further, we postulate that signals from the major input that shape the H3 HC's wiring pattern during development persist to restrict miswiring after damage.
巻・号 7
ページ 10590
公開日 2016-2-3
DOI 10.1038/ncomms10590
PII ncomms10590
PMID 26838932
PMC PMC4742908
MeSH Animals Cues Dendrites / physiology* Immunohistochemistry Microscopy, Confocal Optical Imaging Regeneration / physiology* Retinal Cone Photoreceptor Cells / physiology* Retinal Horizontal Cells / physiology* Retinal Neurons / physiology Synapses / physiology* Ultraviolet Rays Zebrafish
IF 12.121
引用数 19
リソース情報
ゼブラフィッシュ Tg(zfSWS1-5.5A:EGFP) Tg(zfSWS2-3.5A:EGFP)