RRC ID 49720
Author Imada K, Nakamura T.
Title Meiosis-specific localization of the exocytic Rab Ypt2 in fission yeast.
Journal Small GTPases
Abstract Fission yeast Ypt2, an orthologue of the mammalian small GTPase Rab8, is responsible for post-Golgi membrane trafficking. During meiosis, Ypt2 localizes at the spindle pole body (SPB), where it regulates de novo biogenesis of the spore plasma membrane. Recruitment of Ypt2 to the SPB is dependent on its meiosis-specific GDP/GTP exchange factor (GEF), the SPB-resident protein Spo13. Here we have examined the SPB recruitment of Ypt2 by Spo13. The GEF activity of Spo13 was required, but not essential for recruitment. Furthermore, Ypt2 recruitment was regulated in a meiosis-specific manner and partially regulated by the nuclear Dbf2-related (NDR) kinase Sid2, indicating the existence of a novel regulatory mechanism for localization of Rab GTPases during meiosis.
Pages 1-9
Published 2017-9-6
DOI 10.1080/21541248.2017.1356425
PMID 28876998
Resource
Yeast FY15335 FY25772 FY25776 FY25643 FY25646 FY25647 FY31762 FY25658 FY25662 FY31361 FY31365 FY31374 FY31375 FY31377 FY31380 FY31381 FY31382 FY31383 FY31386 FY31387 FY31388 FY31392 FY31393 FY31400 FY31405 FY31409 FY31763 FY31764 FY31765 FY31766 FY21858 FYP3496 FYP3577 FYP3727 FYP3729 FYP3747 FYP3941 FYP3950 FYP3951 FYP3953 FYP3954 FYP220 FYP224