RRC ID 50314
著者 Inada K, Tsuchimoto Y, Kazama H.
タイトル Origins of Cell-Type-Specific Olfactory Processing in the Drosophila Mushroom Body Circuit.
ジャーナル Neuron
Abstract How cell-type-specific physiological properties shape neuronal functions in a circuit remains poorly understood. We addressed this issue in the Drosophila mushroom body (MB), a higher olfactory circuit, where neurons belonging to distinct glomeruli in the antennal lobe feed excitation to three types of intrinsic neurons, α/β, α'/β', and γ Kenyon cells (KCs). Two-photon optogenetics and intracellular recording revealed that whereas glomerular inputs add similarly in all KCs, spikes were generated most readily in α'/β' KCs. This cell type was also the most competent in recruiting GABAergic inhibition fed back by anterior paired lateral neuron, which responded to odors either locally within a lobe or globally across all lobes depending on the strength of stimuli. Notably, as predicted from these physiological properties, α'/β' KCs had the highest odor detection speed, sensitivity, and discriminability. This enhanced discrimination required proper GABAergic inhibition. These results link cell-type-specific mechanisms and functions in the MB circuit.
巻・号 95(2)
ページ 357-367.e4
公開日 2017-7-19
DOI 10.1016/j.neuron.2017.06.039
PII S0896-6273(17)30563-9
PMID 28728024
MeSH Animals Calcium / metabolism* Drosophila melanogaster / physiology Mushroom Bodies / physiology* Neuroimaging / methods Neurons / physiology* Olfactory Bulb / physiology* Patch-Clamp Techniques / methods Smell* Synapses / metabolism
IF 14.415
引用数 10
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