論文 - 詳細
| RRC ID | 50464 |
|---|---|
| 著者 | Nozawa M, Onizuka K, Fujimi M, Ikeo K, Gojobori T. |
| タイトル | Accelerated pseudogenization on the neo-X chromosome in Drosophila miranda. |
| ジャーナル | Nat Commun |
| Abstract |
Y chromosomes often degenerate via the accumulation of pseudogenes and transposable elements. By contrast, little is known about X-chromosome degeneration. Here we compare the pseudogenization process between genes on the neo-sex chromosomes in Drosophila miranda and their autosomal orthologues in closely related species. The pseudogenization rate on the neo-X is much lower than the rate on the neo-Y, but appears to be higher than the rate on the orthologous autosome in D. pseudoobscura. Genes under less functional constraint and/or genes with male-biased expression tend to become pseudogenes on the neo-X, indicating the accumulation of slightly deleterious mutations and the feminization of the neo-X. We also find a weak trend that the genes with female-benefit/male-detriment effects identified in D. melanogaster are pseudogenized on the neo-X, implying the masculinization of the neo-X. These observations suggest that both X and Y chromosomes can degenerate due to a complex suite of evolutionary forces. |
| 巻・号 | 7 |
| ページ | 13659 |
| 公開日 | 2016-11-29 |
| DOI | 10.1038/ncomms13659 |
| PII | ncomms13659 |
| PMID | 27897175 |
| PMC | PMC5141340 |
| MeSH | Animals Drosophila / genetics* Evolution, Molecular Female Feminization Gene Expression Regulation Genes, X-Linked Karyotyping Male Phylogeny Pseudogenes* X Chromosome / genetics* Y Chromosome / genetics |
| IF | 12.121 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | k-s12 |