RRC ID 50464
Author Nozawa M, Onizuka K, Fujimi M, Ikeo K, Gojobori T.
Title Accelerated pseudogenization on the neo-X chromosome in Drosophila miranda.
Journal Nat Commun
Abstract Y chromosomes often degenerate via the accumulation of pseudogenes and transposable elements. By contrast, little is known about X-chromosome degeneration. Here we compare the pseudogenization process between genes on the neo-sex chromosomes in Drosophila miranda and their autosomal orthologues in closely related species. The pseudogenization rate on the neo-X is much lower than the rate on the neo-Y, but appears to be higher than the rate on the orthologous autosome in D. pseudoobscura. Genes under less functional constraint and/or genes with male-biased expression tend to become pseudogenes on the neo-X, indicating the accumulation of slightly deleterious mutations and the feminization of the neo-X. We also find a weak trend that the genes with female-benefit/male-detriment effects identified in D. melanogaster are pseudogenized on the neo-X, implying the masculinization of the neo-X. These observations suggest that both X and Y chromosomes can degenerate due to a complex suite of evolutionary forces.
Volume 7
Pages 13659
Published 2016-11-29
DOI 10.1038/ncomms13659
PII ncomms13659
PMID 27897175
PMC PMC5141340
MeSH Animals Drosophila / genetics* Evolution, Molecular Female Feminization Gene Expression Regulation Genes, X-Linked Karyotyping Male Phylogeny Pseudogenes* X Chromosome / genetics* Y Chromosome / genetics
IF 12.121
Times Cited 4
Drosophila k-s12