Reference - Detail
| RRC ID | 50464 |
|---|---|
| Author | Nozawa M, Onizuka K, Fujimi M, Ikeo K, Gojobori T. |
| Title | Accelerated pseudogenization on the neo-X chromosome in Drosophila miranda. |
| Journal | Nat Commun |
| Abstract |
Y chromosomes often degenerate via the accumulation of pseudogenes and transposable elements. By contrast, little is known about X-chromosome degeneration. Here we compare the pseudogenization process between genes on the neo-sex chromosomes in Drosophila miranda and their autosomal orthologues in closely related species. The pseudogenization rate on the neo-X is much lower than the rate on the neo-Y, but appears to be higher than the rate on the orthologous autosome in D. pseudoobscura. Genes under less functional constraint and/or genes with male-biased expression tend to become pseudogenes on the neo-X, indicating the accumulation of slightly deleterious mutations and the feminization of the neo-X. We also find a weak trend that the genes with female-benefit/male-detriment effects identified in D. melanogaster are pseudogenized on the neo-X, implying the masculinization of the neo-X. These observations suggest that both X and Y chromosomes can degenerate due to a complex suite of evolutionary forces. |
| Volume | 7 |
| Pages | 13659 |
| Published | 2016-11-29 |
| DOI | 10.1038/ncomms13659 |
| PII | ncomms13659 |
| PMID | 27897175 |
| PMC | PMC5141340 |
| MeSH | Animals Drosophila / genetics* Evolution, Molecular Female Feminization Gene Expression Regulation Genes, X-Linked Karyotyping Male Phylogeny Pseudogenes* X Chromosome / genetics* Y Chromosome / genetics |
| IF | 12.121 |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | k-s12 |