| RRC ID |
50464
|
| 著者 |
Nozawa M, Onizuka K, Fujimi M, Ikeo K, Gojobori T.
|
| タイトル |
Accelerated pseudogenization on the neo-X chromosome in Drosophila miranda.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Y chromosomes often degenerate via the accumulation of pseudogenes and transposable elements. By contrast, little is known about X-chromosome degeneration. Here we compare the pseudogenization process between genes on the neo-sex chromosomes in Drosophila miranda and their autosomal orthologues in closely related species. The pseudogenization rate on the neo-X is much lower than the rate on the neo-Y, but appears to be higher than the rate on the orthologous autosome in D. pseudoobscura. Genes under less functional constraint and/or genes with male-biased expression tend to become pseudogenes on the neo-X, indicating the accumulation of slightly deleterious mutations and the feminization of the neo-X. We also find a weak trend that the genes with female-benefit/male-detriment effects identified in D. melanogaster are pseudogenized on the neo-X, implying the masculinization of the neo-X. These observations suggest that both X and Y chromosomes can degenerate due to a complex suite of evolutionary forces.
|
| 巻・号 |
7
|
| ページ |
13659
|
| 公開日 |
2016-11-29
|
| DOI |
10.1038/ncomms13659
|
| PII |
ncomms13659
|
| PMID |
27897175
|
| PMC |
PMC5141340
|
| MeSH |
Animals
Drosophila / genetics*
Evolution, Molecular
Female
Feminization
Gene Expression Regulation
Genes, X-Linked
Karyotyping
Male
Phylogeny
Pseudogenes*
X Chromosome / genetics*
Y Chromosome / genetics
|
| IF |
12.121
|
| 引用数 |
4
|
| リソース情報 |
| ショウジョウバエ |
k-s12 |
