| RRC ID |
50554
|
| 著者 |
Watanabe Y, Furukawa E, Tatsukawa H, Hashimoto H, Kamei Y, Taniguchi Y, Hitomi K.
|
| タイトル |
Higher susceptibility to osmolality of the medaka (Oryzias latipes) mutants in orthologue genes of mammalian skin transglutaminases.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
Transglutaminase (TG) is an essential enzyme to catalyze cross-linking reactions of epidermal proteins. Recently, we biochemically characterized human skin TG orthologues for medaka (Oryzias latipes), a model fish. By genome editing, gene-modified fishes for the two orthologues were obtained, both of which lack the ordinal enzymes. These fish appeared to exhibit higher susceptibility to osmolality at the period of larvae.
|
| 巻・号 |
82(7)
|
| ページ |
1165-1168
|
| 公開日 |
2018-7-1
|
| DOI |
10.1080/09168451.2018.1453294
|
| PMID |
29570037
|
| MeSH |
Amino Acid Sequence
Animals
Animals, Genetically Modified
Female
Fish Proteins / genetics*
Gene Editing
Humans
Larva / physiology
Male
Mutation*
Oryzias / genetics
Oryzias / growth & development
Oryzias / physiology*
Osmolar Concentration*
Skin / enzymology*
Transglutaminases / chemistry
Transglutaminases / genetics*
|
| IF |
1.516
|
| 引用数 |
2
|
| リソース情報 |
| メダカ |
OlTGK2(W368X) (MT997)
OlTGK1(ins2) (MT1118)
OlTGK1(ins2);OlTGK2(W368X) (MT1201)
OK-Cab (MT830) |
