RRC ID 50554
著者 Watanabe Y, Furukawa E, Tatsukawa H, Hashimoto H, Kamei Y, Taniguchi Y, Hitomi K.
タイトル Higher susceptibility to osmolality of the medaka (Oryzias latipes) mutants in orthologue genes of mammalian skin transglutaminases.
ジャーナル Biosci Biotechnol Biochem
Abstract Transglutaminase (TG) is an essential enzyme to catalyze cross-linking reactions of epidermal proteins. Recently, we biochemically characterized human skin TG orthologues for medaka (Oryzias latipes), a model fish. By genome editing, gene-modified fishes for the two orthologues were obtained, both of which lack the ordinal enzymes. These fish appeared to exhibit higher susceptibility to osmolality at the period of larvae.
巻・号 82(7)
ページ 1165-1168
公開日 2018-7-1
DOI 10.1080/09168451.2018.1453294
PMID 29570037
MeSH Amino Acid Sequence Animals Animals, Genetically Modified Female Fish Proteins / genetics* Gene Editing Humans Larva / physiology Male Mutation* Oryzias / genetics Oryzias / growth & development Oryzias / physiology* Osmolar Concentration* Skin / enzymology* Transglutaminases / chemistry Transglutaminases / genetics*
IF 1.516
引用数 2
リソース情報
メダカ OlTGK2(W368X) (MT997) OlTGK1(ins2) (MT1118) OlTGK1(ins2);OlTGK2(W368X) (MT1201) OK-Cab (MT830)