論文 - 詳細
| RRC ID | 50854 |
|---|---|
| 著者 | Aiba Y, Ishikawa H, Tokunaga M, Komatsu Y. |
| タイトル | Anti-Helicobacter pylori activity of non-living, heat-killed form of lactobacilli including Lactobacillus johnsonii No.1088. |
| ジャーナル | FEMS Microbiol Lett |
| Abstract |
Some strains of lactic acid bacteria are reported to inhibit the growth of Helicobacter pylori and proposed to be useful to support so-called triple therapy for H. pylori. Although most strains must be alive to exert their anti-H. pylori activity, some lactobacilli strains are effective even when dead. One possible underlying mechanism of such an activity of non-living lactobacilli is reportedly co-aggregation with H. pylori. In this study, we found that a non-living heat-killed form of Lactobacillus johnsonii No.1088 (HK-LJ88) and also that of some other lactobacilli inhibited the growth of H. pylori in vitro. Furthermore, the number of H. pylori in the infected stomach of germ-free mice was significantly decreased by the repeated oral administration of HK-LJ88. Observation by scanning electron microscopy revealed that no co-aggregation had occurred between H. pylori and HK-LJ88; instead, deformations of H. pylori (e.g. disappearance of spiral, bending of cell body, coccoid formation, degradations, etc.) appeared after incubation for 24 h with HK-LJ88. These results suggest that HK-LJ88 inhibited H. pylori activity probably not by co-aggregation but by some unknown mechanism involving HK-LJ88's cell surface molecules and that even non-living lactobacilli are possibly useful to support H. pylori eradication therapy. |
| 巻・号 | 364(11) |
| 公開日 | 2017-6-15 |
| DOI | 10.1093/femsle/fnx102 |
| PII | 3827362 |
| PMID | 28505287 |
| MeSH | Animals Antibiosis* Disease Models, Animal Female Helicobacter Infections / therapy Helicobacter pylori / growth & development* Hot Temperature Lactobacillus / classification Lactobacillus / physiology* Lactobacillus johnsonii / physiology* Male Mice Mice, Inbred BALB C Probiotics Stomach / microbiology |
| IF | 1.987 |
| 引用数 | 9 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1132 JCM 1059 JCM 1173 JCM 1131 JCM 2012 JCM 1134 JCM 1558 JCM 1149 JCM 1112 |