| RRC ID |
50854
|
| 著者 |
Aiba Y, Ishikawa H, Tokunaga M, Komatsu Y.
|
| タイトル |
Anti-Helicobacter pylori activity of non-living, heat-killed form of lactobacilli including Lactobacillus johnsonii No.1088.
|
| ジャーナル |
FEMS Microbiol Lett
|
| Abstract |
Some strains of lactic acid bacteria are reported to inhibit the growth of Helicobacter pylori and proposed to be useful to support so-called triple therapy for H. pylori. Although most strains must be alive to exert their anti-H. pylori activity, some lactobacilli strains are effective even when dead. One possible underlying mechanism of such an activity of non-living lactobacilli is reportedly co-aggregation with H. pylori. In this study, we found that a non-living heat-killed form of Lactobacillus johnsonii No.1088 (HK-LJ88) and also that of some other lactobacilli inhibited the growth of H. pylori in vitro. Furthermore, the number of H. pylori in the infected stomach of germ-free mice was significantly decreased by the repeated oral administration of HK-LJ88. Observation by scanning electron microscopy revealed that no co-aggregation had occurred between H. pylori and HK-LJ88; instead, deformations of H. pylori (e.g. disappearance of spiral, bending of cell body, coccoid formation, degradations, etc.) appeared after incubation for 24 h with HK-LJ88. These results suggest that HK-LJ88 inhibited H. pylori activity probably not by co-aggregation but by some unknown mechanism involving HK-LJ88's cell surface molecules and that even non-living lactobacilli are possibly useful to support H. pylori eradication therapy.
|
| 巻・号 |
364(11)
|
| 公開日 |
2017-6-15
|
| DOI |
10.1093/femsle/fnx102
|
| PII |
3827362
|
| PMID |
28505287
|
| MeSH |
Animals
Antibiosis*
Disease Models, Animal
Female
Helicobacter Infections / therapy
Helicobacter pylori / growth & development*
Hot Temperature
Lactobacillus / classification
Lactobacillus / physiology*
Lactobacillus johnsonii / physiology*
Male
Mice
Mice, Inbred BALB C
Probiotics
Stomach / microbiology
|
| IF |
1.987
|
| 引用数 |
9
|
| リソース情報 |
| 一般微生物 |
JCM 1132
JCM 1059
JCM 1173
JCM 1131
JCM 2012
JCM 1134
JCM 1558
JCM 1149
JCM 1112 |
