論文 - 詳細
| RRC ID | 51331 |
|---|---|
| 著者 | Delaney CE, Chen AT, Graniel JV, Dumas KJ, Hu PJ. |
| タイトル | A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity. |
| ジャーナル | Development |
| Abstract |
Animals change developmental fates in response to external cues. In the nematode Caenorhabditis elegans, unfavorable environmental conditions induce a state of diapause known as dauer by inhibiting the conserved DAF-2 insulin-like signaling (ILS) pathway through incompletely understood mechanisms. We have previously established a role for the C. elegans dosage compensation protein DPY-21 in the control of dauer arrest and DAF-2 ILS. Here, we show that the histone H4 lysine 20 methyltransferase SET-4, which also influences dosage compensation, promotes dauer arrest in part by repressing the X-linked ins-9 gene, which encodes a new agonist insulin-like peptide (ILP) expressed specifically in the paired ASI sensory neurons that are required for dauer bypass. ins-9 repression in dauer-constitutive mutants requires DPY-21, SET-4 and the FoxO transcription factor DAF-16, which is the main target of DAF-2 ILS. By contrast, autosomal genes encoding major agonist ILPs that promote reproductive development are not repressed by DPY-21, SET-4 or DAF-16/FoxO. Our results implicate SET-4 as a sensory rheostat that reinforces developmental fates in response to environmental cues by modulating autocrine and paracrine DAF-2 ILS. |
| 巻・号 | 144(7) |
| ページ | 1273-1282 |
| 公開日 | 2017-4-1 |
| DOI | 10.1242/dev.145722 |
| PII | dev.145722 |
| PMID | 28209779 |
| PMC | PMC5399626 |
| MeSH | Animals Caenorhabditis elegans / enzymology* Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / metabolism* Environment* Female Gene Expression Profiling Gene Expression Regulation, Developmental Genes, X-Linked Histone-Lysine N-Methyltransferase / metabolism* Histones / metabolism* Larva / metabolism Lysine / metabolism* Male Models, Biological Mutation / genetics Neuronal Plasticity* Sensory Receptor Cells / physiology* Sex Characteristics Transcriptome / genetics |
| IF | 5.611 |
| 引用数 | 8 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1907 tm3188 tm3618 |