論文 - 詳細
| RRC ID | 51344 |
|---|---|
| 著者 | Mitani S. |
| タイトル | Comprehensive functional genomics using Caenorhabditis elegans as a model organism. |
| ジャーナル | Proc Jpn Acad Ser B Phys Biol Sci |
| Abstract |
We have been working on functional genomics using C. elegans as a model organism. We first used cell-type specific markers and preexisting mutants to investigate how genotype-phenotype causal relationships are regulated. With the aid of transgenic methods, we analyzed various biological processes in C. elegans. We have developed efficient methods to isolate gene knockout strains. Thousands of strains isolated this way are used by many researchers and have revealed many biological mechanisms. We have also developed methods to examine the functions of genes in a comprehensive manner by integrating transgenes into chromosomes, designing conditional knockouts, and creating balancers for lethal mutations. A combination of these biological resources and techniques will be useful to understand the functions of genes in C. elegans, which has many genes that are orthologous to those of higher organisms including humans. |
| 巻・号 | 93(8) |
| ページ | 561-577 |
| 公開日 | 2017-1-1 |
| DOI | 10.2183/pjab.93.036 |
| PMID | 29021508 |
| PMC | PMC5743858 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics* Chromosomes / genetics Gene Expression Profiling / methods Gene Knockout Techniques / methods Genomics / methods* Models, Animal Mutation Transgenes |
| IF | 3.0 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm698 |