RRC ID 51359
Author Liu F, Xiao Y, Ji XL, Zhang KQ, Zou CG.
Title The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans.
Journal Sci Rep
Abstract Low temperature has a great impact on animal life. Homoiotherms such as mammals increase their energy expenditure to produce heat by activating the cAMP-protein kinase A (PKA)-hormone-sensitive lipase (HSL) pathway under cold stress. Although poikilothermic animals do not have the ability to regulate body temperature, whether this pathway is required for cold tolerance remains unknown. We have now achieved this using the genetically tractable model animal Caenorhabditis elegans. We demonstrate that cold stress activates PKA signaling, which in turn up-regulates the expression of a hormone-sensitive lipase hosl-1. The lipase induces fat mobilization, leading to glycerol accumulation, thereby protecting worms against cold stress. Our findings provide an example of an evolutionarily conserved mechanism for cold tolerance that has persisted in both poikilothermic and homoeothermic animals.
Volume 7(1)
Pages 638
Published 2017-4-4
DOI 10.1038/s41598-017-00630-w
PII 10.1038/s41598-017-00630-w
PMID 28377576
PMC PMC5428847
MeSH Adaptation, Biological* Adipose Tissue / metabolism* Animals Animals, Genetically Modified Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cold Temperature* Cyclic AMP / metabolism* Cyclic AMP-Dependent Protein Kinase Catalytic Subunits / genetics Cyclic AMP-Dependent Protein Kinase Catalytic Subunits / metabolism Cyclic AMP-Dependent Protein Kinases / metabolism* Lipid Metabolism Lipolysis Neurons / metabolism Signal Transduction* Stress, Physiological
IF 3.998
Times Cited 9
C.elegans tm5028