| RRC ID |
51359
|
| 著者 |
Liu F, Xiao Y, Ji XL, Zhang KQ, Zou CG.
|
| タイトル |
The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans.
|
| ジャーナル |
Sci Rep
|
| Abstract |
Low temperature has a great impact on animal life. Homoiotherms such as mammals increase their energy expenditure to produce heat by activating the cAMP-protein kinase A (PKA)-hormone-sensitive lipase (HSL) pathway under cold stress. Although poikilothermic animals do not have the ability to regulate body temperature, whether this pathway is required for cold tolerance remains unknown. We have now achieved this using the genetically tractable model animal Caenorhabditis elegans. We demonstrate that cold stress activates PKA signaling, which in turn up-regulates the expression of a hormone-sensitive lipase hosl-1. The lipase induces fat mobilization, leading to glycerol accumulation, thereby protecting worms against cold stress. Our findings provide an example of an evolutionarily conserved mechanism for cold tolerance that has persisted in both poikilothermic and homoeothermic animals.
|
| 巻・号 |
7(1)
|
| ページ |
638
|
| 公開日 |
2017-4-4
|
| DOI |
10.1038/s41598-017-00630-w
|
| PII |
10.1038/s41598-017-00630-w
|
| PMID |
28377576
|
| PMC |
PMC5428847
|
| MeSH |
Adaptation, Biological*
Adipose Tissue / metabolism*
Animals
Animals, Genetically Modified
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism
Cold Temperature*
Cyclic AMP / metabolism*
Cyclic AMP-Dependent Protein Kinase Catalytic Subunits / genetics
Cyclic AMP-Dependent Protein Kinase Catalytic Subunits / metabolism
Cyclic AMP-Dependent Protein Kinases / metabolism*
Lipid Metabolism
Lipolysis
Neurons / metabolism
Signal Transduction*
Stress, Physiological
|
| IF |
3.998
|
| 引用数 |
9
|
| リソース情報 |
| 線虫 |
tm5028 |
