論文 - 詳細
| RRC ID | 51363 |
|---|---|
| 著者 | Banerjee N, Bhattacharya R, Gorczyca M, Collins KM, Francis MM. |
| タイトル | Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior. |
| ジャーナル | PLoS Genet |
| Abstract |
Animal behaviors are often composed of distinct alternating behavioral states. Neuromodulatory signals are thought to be critical for establishing stable behavioral states and for orchestrating transitions between them. However, we have only a limited understanding of how neuromodulatory systems act in vivo to alter circuit performance and shape behavior. To address these questions, we have investigated neuromodulatory signaling in the context of Caenorhabditis elegans egg-laying. Egg-laying activity cycles between discrete states-short bursts of egg deposition (active phases) that alternate with prolonged quiescent periods (inactive phases). Here using genetic, pharmacological and optogenetic approaches for cell-specific activation and inhibition, we show that a group of neurosecretory cells (uv1) located in close spatial proximity to the egg-laying neuromusculature direct the temporal organization of egg-laying by prolonging the duration of inactive phases. We demonstrate that the modulatory effects of the uv1 cells are mediated by peptides encoded by the nlp-7 and flp-11 genes that act locally to inhibit circuit activity, primarily by inhibiting vesicular release of serotonin from HSN motor neurons. This peptidergic inhibition is achieved, at least in part, by reducing synaptic vesicle abundance in the HSN motor neurons. By linking the in vivo actions of specific neuropeptide signaling systems with the generation of stable behavioral outcomes, our study reveals how cycles of neuromodulation emanating from non-neuronal cells can fundamentally shape the organization of a behavioral program. |
| 巻・号 | 13(4) |
| ページ | e1006697 |
| 公開日 | 2017-4-1 |
| DOI | 10.1371/journal.pgen.1006697 |
| PII | PGENETICS-D-16-02508 |
| PMID | 28384151 |
| PMC | PMC5398689 |
| MeSH | Acetylcholine / metabolism Animals Behavior, Animal Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics* Motor Neurons / metabolism Neuropeptides / genetics* Neuropeptides / metabolism Neurosecretion / genetics Oviposition / genetics* Serotonergic Neurons / metabolism Serotonin / metabolism Signal Transduction / genetics |
| IF | 5.175 |
| 引用数 | 8 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2706 tm2709 tm2984 |