論文 - 詳細
| RRC ID | 51375 |
|---|---|
| 著者 | Tang H, Han M. |
| タイトル | Fatty Acids Regulate Germline Sex Determination through ACS-4-Dependent Myristoylation. |
| ジャーナル | Cell |
| Abstract |
Fat metabolism has been linked to fertility and reproductive adaptation in animals and humans, and environmental sex determination potentially plays a role in the process. To investigate the impact of fatty acids (FA) on sex determination and reproductive development, we examined and observed an impact of FA synthesis and mobilization by lipolysis in somatic tissues on oocyte fate in Caenorhabditis elegans. The subsequent genetic analysis identified ACS-4, an acyl-CoA synthetase and its FA-CoA product, as key germline factors that mediate the role of FA in promoting oocyte fate through protein myristoylation. Further tests indicated that ACS-4-dependent protein myristoylation perceives and translates the FA level into regulatory cues that modulate the activities of MPK-1/MAPK and key factors in the germline sex-determination pathway. These findings, including a similar role of ACS-4 in a male/female species, uncover a likely conserved mechanism by which FA, an environmental factor, regulates sex determination and reproductive development. |
| 巻・号 | 169(3) |
| ページ | 457-469.e13 |
| 公開日 | 2017-4-20 |
| DOI | 10.1016/j.cell.2017.03.049 |
| PII | S0092-8674(17)30411-7 |
| PMID | 28431246 |
| MeSH | Acetate-CoA Ligase / genetics Acetate-CoA Ligase / metabolism* Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Fatty Acids / metabolism* Mutation Myristic Acid / metabolism* Oocytes / metabolism Protein Processing, Post-Translational* Sex Determination Processes* |
| IF | 38.637 |
| 引用数 | 14 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 52 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3480 tm4063 |