Reference - Detail
| RRC ID | 51382 |
|---|---|
| Author | Lee J, Yue Y, Park Y, Lee SH. |
| Title | 3,3'-Diindolylmethane Suppresses Adipogenesis Using AMPKα-Dependent Mechanism in 3T3-L1 Adipocytes and Caenorhabditis elegans. |
| Journal | J Med Food |
| Abstract |
3,3'-diindolylmethane is a major in vivo metabolite of indole-3-carbinol, a bioactive compound found in cruciferous vegetables. Although 3,3'-diindolylmethane has been implicated to possess antitumorigenic and anti-inflammatory properties, the effect of 3,3'-diindolylmethane on adipogenesis has not been explored previously. Thus, the present study was conducted to determine if 3,3'-diindolylmethane affects adipogenesis using 3T3-L1 adipocytes and Caenorhabditis elegans. Treatment of 3,3'-diindolylmethane significantly reduced fat accumulation without affecting viability in 3T3-L1 adipocytes. 3,3'-diindolylmethane suppressed expression of peroxisome proliferator-activated receptor γ (PPARγ), CCAAT-enhancer-binding protein α (C/EBPα), fatty acid binding protein 4 (FABP4), and perilipin. In addition, 3,3'-diindolylmethane activated AMP-activated protein kinase α (AMPKα), which subsequently inactivated acetyl CoA carboxylase (ACC), resulting in reduced fat accumulation. These observations were further confirmed in C. elegans as treatment with 3,3'-diindolylmethane significantly reduced body fat accumulation, which was partly associated with aak-1, but not aak-2, orthologs of AMPKα catalytic subunits α1 and α2, respectively. The current results demonstrate that 3,3'-diindolylmethane, a biologically active metabolite of indole-3-carbinol, may prevent adipogenesis through the AMPKα-dependent pathway. |
| Volume | 20(7) |
| Pages | 646-652 |
| Published | 2017-7-1 |
| DOI | 10.1089/jmf.2016.0165 |
| PMID | 28459610 |
| MeSH | 3T3 Cells AMP-Activated Protein Kinases / genetics AMP-Activated Protein Kinases / metabolism* Adipocytes / cytology Adipocytes / drug effects* Adipocytes / enzymology Adipocytes / metabolism Adipogenesis / drug effects* Animals CCAAT-Enhancer-Binding Protein-alpha / genetics CCAAT-Enhancer-Binding Protein-alpha / metabolism Caenorhabditis elegans / drug effects Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cell Survival / drug effects Fatty Acid-Binding Proteins / genetics Fatty Acid-Binding Proteins / metabolism Indoles / pharmacology* Mice PPAR gamma / genetics PPAR gamma / metabolism Triglycerides / metabolism |
| IF | 2.04 |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1944 |