Reference - Detail
| RRC ID | 51398 |
|---|---|
| Author | Oda S, Toyoshima Y, de Bono M. |
| Title | Modulation of sensory information processing by a neuroglobin in Caenorhabditis elegans. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The roundworm Caenorhabditis elegans avoids 21% O2 and hypoxia and prefers intermediate O2 concentrations. We show how this O2 preference is sculpted by the antagonistic action of a neuroglobin and an O2-binding soluble guanylate cyclase. These putative molecular O2 sensors confer a sigmoidal O2 response curve in the URX neurons that has highest slope between 15 and 19% O2 and approaches saturation when O2 reaches 21%. In the absence of the neuroglobin, the response curve is shifted to lower O2 values and approaches saturation at 14% O2 In behavioral terms, neuroglobin signaling broadens the O2 preference of Caenorhabditis elegans while maintaining avoidance of 21% O2 A computational model of aerotaxis suggests the relationship between GLB-5-modulated URX responses and reversal behavior is sufficient to broaden O2 preference. In summary, we show that a neuroglobin can shift neural information coding leading to altered behavior. Antagonistically acting molecular sensors may represent a common mechanism to sharpen tuning of sensory neurons. |
| Volume | 114(23) |
| Pages | E4658-E4665 |
| Published | 2017-6-6 |
| DOI | 10.1073/pnas.1614596114 |
| PII | 1614596114 |
| PMID | 28536200 |
| PMC | PMC5468664 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Cyclic GMP / metabolism Genes, Helminth Globins / genetics Globins / physiology* Guanylate Cyclase / metabolism Models, Neurological Mutation Nerve Tissue Proteins / genetics Nerve Tissue Proteins / physiology* Neuroglobin Oxygen / metabolism Sensory Receptor Cells / physiology Signal Transduction |
| IF | 9.412 |
| Times Cited | 4 |
| Resource | |
| C.elegans | tm5440 |