RRC ID 51398
Author Oda S, Toyoshima Y, de Bono M.
Title Modulation of sensory information processing by a neuroglobin in Caenorhabditis elegans.
Journal Proc Natl Acad Sci U S A
Abstract Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The roundworm Caenorhabditis elegans avoids 21% O2 and hypoxia and prefers intermediate O2 concentrations. We show how this O2 preference is sculpted by the antagonistic action of a neuroglobin and an O2-binding soluble guanylate cyclase. These putative molecular O2 sensors confer a sigmoidal O2 response curve in the URX neurons that has highest slope between 15 and 19% O2 and approaches saturation when O2 reaches 21%. In the absence of the neuroglobin, the response curve is shifted to lower O2 values and approaches saturation at 14% O2 In behavioral terms, neuroglobin signaling broadens the O2 preference of Caenorhabditis elegans while maintaining avoidance of 21% O2 A computational model of aerotaxis suggests the relationship between GLB-5-modulated URX responses and reversal behavior is sufficient to broaden O2 preference. In summary, we show that a neuroglobin can shift neural information coding leading to altered behavior. Antagonistically acting molecular sensors may represent a common mechanism to sharpen tuning of sensory neurons.
Volume 114(23)
Pages E4658-E4665
Published 2017-6-6
DOI 10.1073/pnas.1614596114
PII 1614596114
PMID 28536200
PMC PMC5468664
MeSH Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Cyclic GMP / metabolism Genes, Helminth Globins / genetics Globins / physiology* Guanylate Cyclase / metabolism Models, Neurological Mutation Nerve Tissue Proteins / genetics Nerve Tissue Proteins / physiology* Neuroglobin Oxygen / metabolism Sensory Receptor Cells / physiology Signal Transduction
IF 9.412
Times Cited 4
C.elegans tm5440