Reference - Detail
| RRC ID | 51418 |
|---|---|
| Author | Sung M, Kawasaki I, Shim YH. |
| Title | Depletion of cdc-25.3, a Caenorhabditis elegans orthologue of cdc25, increases physiological germline apoptosis. |
| Journal | FEBS Lett |
| Abstract |
In Caenorhabditis elegans hermaphrodites, physiological germline apoptosis is higher in cdc-25.3 mutants than in wild-type. The elevated germline apoptosis in cdc-25.3 mutants seems to be induced by accumulation of double-stranded DNA breaks (DSBs). Both DNA damage and synapsis checkpoint genes are required to increase the germline apoptosis. Notably, the number of germ cells that lose P-granule components, PGL-1 and PGL-3, increase in cdc-25.3 mutants, and the increase in germline apoptosis requires the activity of SIR-2.1, a Sirtuin orthologue. These results suggest that elevation of germline apoptosis in cdc-25.3 mutants is induced by accumulation of DSBs, leading to a loss of PGL-1 and PGL-3 in germ cells, which promotes cytoplasmic translocation of SIR-2.1, and finally activates the core apoptotic machinery. |
| Volume | 591(14) |
| Pages | 2131-2146 |
| Published | 2017-7-1 |
| DOI | 10.1002/1873-3468.12717 |
| PMID | 28627101 |
| MeSH | Animals Apoptosis / genetics* Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Chromosome Pairing DNA Breaks, Double-Stranded Disorders of Sex Development / genetics Gene Deletion* Male Meiosis Sequence Homology, Nucleic Acid* Spermatozoa / cytology* cdc25 Phosphatases / genetics* cdc25 Phosphatases / metabolism |
| IF | 3.057 |
| Times Cited | 2 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2420 |