Reference - Detail
RRC ID | 51418 |
---|---|
Author | Sung M, Kawasaki I, Shim YH. |
Title | Depletion of cdc-25.3, a Caenorhabditis elegans orthologue of cdc25, increases physiological germline apoptosis. |
Journal | FEBS Lett |
Abstract |
In Caenorhabditis elegans hermaphrodites, physiological germline apoptosis is higher in cdc-25.3 mutants than in wild-type. The elevated germline apoptosis in cdc-25.3 mutants seems to be induced by accumulation of double-stranded DNA breaks (DSBs). Both DNA damage and synapsis checkpoint genes are required to increase the germline apoptosis. Notably, the number of germ cells that lose P-granule components, PGL-1 and PGL-3, increase in cdc-25.3 mutants, and the increase in germline apoptosis requires the activity of SIR-2.1, a Sirtuin orthologue. These results suggest that elevation of germline apoptosis in cdc-25.3 mutants is induced by accumulation of DSBs, leading to a loss of PGL-1 and PGL-3 in germ cells, which promotes cytoplasmic translocation of SIR-2.1, and finally activates the core apoptotic machinery. |
Volume | 591(14) |
Pages | 2131-2146 |
Published | 2017-7-1 |
DOI | 10.1002/1873-3468.12717 |
PMID | 28627101 |
MeSH | Animals Apoptosis / genetics* Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Chromosome Pairing DNA Breaks, Double-Stranded Disorders of Sex Development / genetics Gene Deletion* Male Meiosis Sequence Homology, Nucleic Acid* Spermatozoa / cytology* cdc25 Phosphatases / genetics* cdc25 Phosphatases / metabolism |
IF | 3.057 |
Times Cited | 2 |
Resource | |
C.elegans | tm2420 |