RRC ID 51456
著者 Park D, Hahm JH, Park S, Ha G, Chang GE, Jeong H, Kim H, Kim S, Cheong E, Paik YK.
タイトル A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans.
ジャーナル Sci Rep
Abstract Animals use pheromones as a conspecific chemical language to respond appropriately to environmental changes. The soil nematode Caenorhabditis elegans secretes ascaroside pheromones throughout the lifecycle, which influences entry into dauer phase in early larvae, in addition to sexual attraction and aggregation. In adult hermaphrodites, pheromone sensory signals perceived by worms usually elicit repulsion as an initial behavioral signature. However, the molecular mechanisms underlying neuronal pheromone sensory process from perception to repulsion in adult hermaphrodites remain poorly understood. Here, we show that pheromone signals perceived by GPA-3 is conveyed through glutamatergic neurotransmission in which neuronal DAF-16/FoxO plays an important modulatory role by controlling glutaminase gene expression. We further provide evidence that this modulatory role for DAF-16/FoxO seems to be conserved evolutionarily by electro-physiological study in mouse primary hippocampal neurons that are responsible for glutamatergic neurotransmission. These findings provide the basis for understanding the nematode pheromone signaling, which seems crucial for adaptation of adult hermaphrodites to changes in environmental condition for survival.
巻・号 7(1)
ページ 7260
公開日 2017-8-3
DOI 10.1038/s41598-017-07313-6
PII 10.1038/s41598-017-07313-6
PMID 28775361
PMC PMC5543152
MeSH Animals Behavior, Animal Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* Forkhead Transcription Factors / genetics* Forkhead Transcription Factors / metabolism* GTP-Binding Protein alpha Subunits, Gi-Go / genetics GTP-Binding Protein alpha Subunits, Gi-Go / metabolism Gene Expression Regulation Glutamic Acid / metabolism Glutaminase / genetics Glutaminase / metabolism Insulin / metabolism Insulin-Like Growth Factor I / metabolism Neurons / metabolism* Pheromones / metabolism* Signal Transduction* Synaptic Transmission
IF 3.998
引用数 10
リソース情報
線虫 tm1811