論文 - 詳細
| RRC ID | 51457 |
|---|---|
| 著者 | Chaudhari SN, Kipreos ET. |
| タイトル | Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways. |
| ジャーナル | Nat Commun |
| Abstract |
Mitochondria are dynamic organelles that undergo fusion and fission events. Mitochondrial dynamics are required for mitochondrial viability and for responses to changes in bioenergetic status. Here we describe an insulin-signaling and SCFLIN-23-regulated pathway that controls mitochondrial fusion in Caenorhabditis elegans by repressing the expression of the mitochondrial proteases SPG-7 and PPGN-1. This pathway is required for mitochondrial fusion in response to physical exertion, and for the associated extension in lifespan. We show that diverse longevity pathways exhibit increased levels of elongated mitochondria. The increased mitochondrial fusion is essential for longevity in the diverse longevity pathways, as inhibiting mitochondrial fusion reduces their lifespans to wild-type levels. Our results suggest that increased mitochondrial fusion is not a major driver of longevity, but rather is essential to allow the survival of older animals beyond their normal lifespan in diverse longevity pathways.Mitochondria can undergo shape changes as a result of fusion and fission events. Here the authors describe how insulin signalling regulates mitochondrial fusion in C. elegans, and show that mitochondrial fusion is necessary, but not sufficient, for longevity of worms with mutations that increase lifespan. |
| 巻・号 | 8(1) |
| ページ | 182 |
| 公開日 | 2017-8-3 |
| DOI | 10.1038/s41467-017-00274-4 |
| PII | 10.1038/s41467-017-00274-4 |
| PMID | 28769038 |
| PMC | PMC5541002 |
| MeSH | ATPases Associated with Diverse Cellular Activities / metabolism Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / metabolism* Cell Cycle Proteins / metabolism* Energy Metabolism F-Box Proteins / metabolism* Insulin / metabolism* Insulin-Like Growth Factor I / metabolism* Longevity* Mitochondrial Dynamics* Signal Transduction Ubiquitin-Protein Ligases / metabolism |
| IF | 12.121 |
| 引用数 | 28 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 33 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1683 tm2312 |