Reference - Detail
| RRC ID | 51544 |
|---|---|
| Author | Doitsidou M, Minevich G, Kroll JR, Soete G, Gowtham S, Korswagen HC, Sebastiaan van Zon J, Hobert O. |
| Title | A Caenorhabditis elegans Zinc Finger Transcription Factor, ztf-6, Required for the Specification of a Dopamine Neuron-Producing Lineage. |
| Journal | G3 (Bethesda) |
| Abstract |
Invertebrate and vertebrate nervous systems generate different types of dopaminergic neurons in distinct parts of the brain. We have taken a genetic approach to understand how the four functionally related, but lineally unrelated, classes of dopaminergic neurons of the nematode Caenorhabditis elegans, located in distinct parts of its nervous system, are specified. We have identified several genes involved in the generation of a specific dopaminergic neuron type that is generated from the so-called postdeirid lineage, called PDE. Apart from classic proneural genes and components of the mediator complex, we identified a novel, previously uncharacterized zinc finger transcription factor, ztf-6 Loss of ztf-6 has distinct effects in different dopamine neuron-producing neuronal lineages. In the postdeirid lineage, ztf-6 is required for proper cell division patterns and the proper distribution of a critical cell fate determinant, the POP-1/TCF-like transcription factor. |
| Volume | 8(1) |
| Pages | 17-26 |
| Published | 2018-1-4 |
| DOI | 10.1534/g3.117.300132 |
| PII | g3.117.300132 |
| PMID | 29301976 |
| PMC | PMC5765345 |
| MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Cell Differentiation Cell Division Cell Lineage / genetics DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism Dopamine / metabolism Dopaminergic Neurons / classification Dopaminergic Neurons / cytology Dopaminergic Neurons / metabolism* Gene Expression Regulation, Developmental* High Mobility Group Proteins / genetics High Mobility Group Proteins / metabolism Mutation Transcription Factors / genetics* Transcription Factors / metabolism Zinc Fingers* |
| IF | 2.781 |
| Times Cited | 1 |
| Resource | |
| C.elegans | tm3740 |