RRC ID 51875
Author Izumi Y, Fujii K, Yamamoto S, Matsuo K, Namatame H, Taniguchi M, Yokoya A.
Title DNA damage response induces structural alterations in histone H3-H4.
Journal J Radiat Res
Abstract Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our previously reported results for histone H2A-H2B. These results strongly suggest that histones share roles in DNA damage responses, particularly in DNA repair processes and chromatin remodeling, via a specific structural alteration of each histone.
Volume 58(1)
Pages 59-65
Published 2017-1-1
DOI 10.1093/jrr/rrw086
PII rrw086
PMID 27672100
PMC PMC5321191
MeSH Cell Line, Tumor Circular Dichroism DNA Damage* DNA Repair / radiation effects Electrophoresis, Polyacrylamide Gel Histones / chemistry* Histones / metabolism Humans Protein Structure, Secondary Synchrotrons X-Rays
IF 2.014
Times Cited 6
Resource
Human and Animal Cells HeLa/Fucci(RCB2812)