| RRC ID |
51986
|
| 著者 |
Hijiya N, Shibata T, Daa T, Hamanaka R, Uchida T, Matsuura K, Tsukamoto Y, Nakada C, Iha H, Inomata M, Moriyama M.
|
| タイトル |
Overexpression of cannabinoid receptor 1 in esophageal squamous cell carcinoma is correlated with metastasis to lymph nodes and distant organs, and poor prognosis.
|
| ジャーナル |
Pathol Int
|
| Abstract |
In patients with esophageal squamous cell carcinoma (ESCC), the status of metastasis to lymph nodes is strongly associated with prognosis. Consequently, development of a biomarker to detect the presence of metastasis would be clinically valuable. In this study, we found that overexpression of cannabinoid receptor 1 (CB1R) was applicable as a marker for prediction of metastasis in ESCC. CB1R overexpression was detected immunohistochemically in 54 of 88 cases (61.4%). The intensity of CB1R expression was uniform in both intraepithelial and invasive regions in each case, and was significantly correlated with the status of metastasis to lymph nodes (P = 0.046) and distant organs (P = 0.047). Furthermore, multivariate analysis revealed that CB1R overexpression was independently associated with poor prognosis (P = 0.019). Biological analysis of CB1R overexpression using ESCC cell lines revealed that CB1R activation appeared to promote cell proliferation and invasion. On the basis of these findings, we propose that evaluation of CB1R expression status in biopsy specimens of ESCC using immunohistochemistry might be clinically useful for prediction of metastasis to lymph nodes and distant organs.
|
| 巻・号 |
67(2)
|
| ページ |
83-90
|
| 公開日 |
2017-2-1
|
| DOI |
10.1111/pin.12495
|
| PMID |
27976824
|
| MeSH |
Aged
Area Under Curve
Biomarkers, Tumor / analysis*
Blotting, Western
Carcinoma, Squamous Cell / pathology*
Esophageal Neoplasms / pathology*
Esophageal Squamous Cell Carcinoma
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Lymphatic Metastasis / pathology
Male
Middle Aged
Neoplasm Invasiveness / pathology
Neoplasm Metastasis / pathology*
Prognosis
Proportional Hazards Models
ROC Curve
Receptor, Cannabinoid, CB1 / biosynthesis*
Up-Regulation
|
| IF |
2.11
|
| 引用数 |
5
|
| リソース情報 |
| ヒト・動物細胞 |
TE-1(RCB1894)
TE-8(RCB2098) |
