論文 - 詳細
| RRC ID | 52427 |
|---|---|
| 著者 | Li Z, Jin H, Mao G, Wu L, Guo Q. |
| タイトル | Msi2 plays a carcinogenic role in esophageal squamous cell carcinoma via regulation of the Wnt/β-catenin and Hedgehog signaling pathways. |
| ジャーナル | Exp Cell Res |
| Abstract |
Msi2 has been widely reported to be upregulated and strongly associated with fast progress and poor prognosis in many cancers. However, the expression and role of Msi2 in esophageal squamous cell carcinoma (ESCC) remain unknown. In this study, we found that Msi2 was upregulated in ESCC clinical samples, and was significantly associated with tumor size, differentiation status, and lymph node metastasis in ESCC patients. Multivariate Cox regression analysis showed that Msi2 was an independent predictor for disease-free survival (DFS) and overall survival (OS). Moreover, knockdown of Msi2 impaired ESCC cell proliferation, epithelial-mesenchymal transition (EMT) and migration, while overexpression of Msi2 promoted ESCC cell proliferation, EMT and migration in vitro. Animal experiments also confirmed that Msi2 promoted ESCC cell proliferation in vivo. Mechanistically, Msi2 promoted ESCC cell proliferation, EMT and migration via regulation of the Wnt/β-catenin and Hedgehog (Hh) signaling pathways. Taken together, our study suggested that Msi2 could serve as a candidate for diagnosis and prognosis and as a potential therapeutic target in ESCC. |
| 巻・号 | 361(1) |
| ページ | 170-177 |
| 公開日 | 2017-12-1 |
| DOI | 10.1016/j.yexcr.2017.10.016 |
| PII | S0014-4827(17)30563-3 |
| PMID | 29054489 |
| MeSH | Animals Apoptosis Biomarkers, Tumor / genetics Biomarkers, Tumor / metabolism Carcinoma, Squamous Cell / genetics Carcinoma, Squamous Cell / metabolism Carcinoma, Squamous Cell / pathology* Cell Movement Cell Proliferation Epithelial-Mesenchymal Transition Esophageal Neoplasms / genetics Esophageal Neoplasms / metabolism Esophageal Neoplasms / pathology* Female Gene Expression Regulation, Neoplastic* Hedgehog Proteins / genetics Hedgehog Proteins / metabolism* Humans Lymphatic Metastasis Male Mice Mice, Inbred BALB C Middle Aged Neoplasm Invasiveness Prognosis RNA-Binding Proteins / genetics RNA-Binding Proteins / metabolism* Signal Transduction Tumor Cells, Cultured Wnt1 Protein / genetics Wnt1 Protein / metabolism* Xenograft Model Antitumor Assays beta Catenin / genetics beta Catenin / metabolism |
| IF | 3.383 |
| 引用数 | 13 |
| リソース情報 | |
| ヒト・動物細胞 | TE-6(RCB1950) TE-8(RCB2098) |