RRC ID 52673
Author Yamashita W, Takahashi M, Kikkawa T, Gotoh H, Osumi N, Ono K, Nomura T.
Title Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain.
Journal Development
Abstract expression in the developing pallium is highly divergent in these species. Our results suggest that spatiotemporal changes in Pax6-dependent regulatory programs contributed to species-specific neurogenic patterns in mammalian and avian lineages, which underlie the morphological divergence of the amniote pallial architectures.
Volume 145(8)
Published 2018-4-16
DOI 10.1242/dev.159764
PII 145/8/dev159764
PMID 29661783
PMC PMC5964652
MeSH Animals Animals, Genetically Modified Avian Proteins / genetics Avian Proteins / physiology* Brain / embryology* Brain / physiology* Chick Embryo Enhancer Elements, Genetic Evolution, Molecular Female Gene Deletion Gene Expression Regulation, Developmental Homeodomain Proteins / genetics Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Knockout Mice, Transgenic Neurogenesis / genetics Neurogenesis / physiology PAX6 Transcription Factor / deficiency PAX6 Transcription Factor / genetics PAX6 Transcription Factor / physiology* Pregnancy Receptors, Notch / genetics Receptors, Notch / physiology Signal Transduction Species Specificity
IF 5.413
Human and Animal Cells 293T(RCB2202)