RRC ID 52827
Author Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S.
Title Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis.
Journal Innate Immun
Abstract Dermatophytoses are chronic fungal infections, the main causative agent of which is Trichophyton rubrum (T. rubrum). Despite their high occurrence worldwide, the immunological mechanisms underlying these diseases remain largely unknown. Here, we uncovered the C-type lectin receptors, Dectin-1 and Dectin-2, as key elements in the immune response to T. rubrum infection in a model of deep dermatophytosis. In vitro, we observed that deficiency in Dectin-1 and Dectin-2 severely compromised cytokine production by dendritic cells. In vivo, mice lacking Dectin-1 and/or Dectin-2 showed an inadequate pro-inflammatory cytokine production in response to T. rubrum infection, impairing its resolution. Strikingly, neither adaptive immunity nor IL-17 response were required for fungal clearance, highlighting innate immunity as the main checkpoint in the pathogenesis of T. rubrum infection.
Volume 22(5)
Pages 316-24
Published 2016-7-1
DOI 10.1177/1753425916645392
PII 1753425916645392
PMID 27189427
MeSH Adaptive Immunity Animals Cell Differentiation Cells, Cultured Cytokines / metabolism Dendritic Cells / immunology* Humans Immunity Interleukin-17 / metabolism Lectins, C-Type / genetics Lectins, C-Type / metabolism* Mice Mice, Inbred C57BL Mice, Knockout Models, Animal RNA, Small Interfering / genetics Tinea / immunology* Trichophyton / immunology*
IF 2.298
Times Cited 12
Pathogenic microorganisms