RRC ID 52856
Author Shinkai Y, Yoshida MC, Maeda K, Kobata T, Maruyama K, Yodoi J, Yagita H, Okumura K.
Title Molecular cloning and chromosomal assignment of a human perforin (PFP) gene.
Journal Immunogenetics
Abstract Human perforin cDNA was isolated and the complete nucleotide sequence of the gene determined. The deduced amino acid sequence of human perforin showed 68.4% similarity to that of mouse perforin. RNA blot analysis of the human perforin gene revealed that the gene product is expressed preferentially in killer-type cells among cell lines tested, and in large granular lymphocytes among the peripheral blood mononuclear cells. In situ hybridization analysis with a human perforin cDNA probe revealed that the human perforin (PFP) gene is located on chromosome 17q11-21.
Volume 30(6)
Pages 452-7
Published 1989
DOI 10.1007/BF02421177
PMID 2592021
MeSH Base Sequence Blotting, Northern Chromosome Mapping* Chromosomes, Human, Pair 17 Cloning, Molecular* DNA / isolation & purification Humans Membrane Glycoproteins* Membrane Proteins / genetics* Molecular Sequence Data Perforin Pore Forming Cytotoxic Proteins
IF 2.492
Times Cited 61
Resource
DNA material YT101 (RDB01181).