Reference - Detail
| RRC ID | 53217 |
|---|---|
| Author | Kondo A, Fujiwara T, Okitsu Y, Fukuhara N, Onishi Y, Nakamura Y, Sawada K, Harigae H. |
| Title | Identification of a novel putative mitochondrial protein FAM210B associated with erythroid differentiation. |
| Journal | Int J Hematol |
| Abstract |
The transcription factor GATA-1 plays an essential role in erythroid differentiation. To identify novel GATA-1 target genes, we analyzed a merged ChIP-seq and expression profiling dataset. We identified FAM210B as a putative novel GATA-1 target gene. Study results demonstrated that GATA-1 directly regulates FAM210B expression, presumably by binding to an intronic enhancer region. Both human and murine FAM210B are abundantly expressed in the later stages of erythroblast development. Moreover, the deduced amino acid sequence predicted that FAM210B is a membrane protein, and Western blot analysis demonstrated its mitochondrial localization. Loss-of-function analysis in erythroid cells suggested that FAM210B may be involved in erythroid differentiation. The identification and characterization of FAM210B provides new insights in the study of erythropoiesis and hereditary anemias. |
| Volume | 103(4) |
| Pages | 387-95 |
| Published | 2016-4-1 |
| DOI | 10.1007/s12185-016-1968-4 |
| PII | 10.1007/s12185-016-1968-4 |
| PMID | 26968549 |
| MeSH | Cell Line Erythroblasts / cytology* Erythroblasts / metabolism Erythroid Cells / cytology* Erythroid Cells / metabolism Erythropoiesis* GATA1 Transcription Factor / genetics GATA1 Transcription Factor / metabolism* Gene Expression Regulation, Developmental HEK293 Cells Humans Introns Membrane Proteins / genetics Membrane Proteins / metabolism* Mitochondrial Proteins / genetics Mitochondrial Proteins / metabolism* RNA Interference RNA, Small Interfering / genetics |
| IF | 2.245 |
| Times Cited | 4 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Cord blood stem cells for research | |