RRC ID 53255
著者 Wallace SW, Singhvi A, Liang Y, Lu Y, Shaham S.
タイトル PROS-1/Prospero Is a Major Regulator of the Glia-Specific Secretome Controlling Sensory-Neuron Shape and Function in C. elegans.
ジャーナル Cell Rep
Abstract Sensory neurons are an animal's gateway to the world, and their receptive endings, the sites of sensory signal transduction, are often associated with glia. Although glia are known to promote sensory-neuron functions, the molecular bases of these interactions are poorly explored. Here, we describe a post-developmental glial role for the PROS-1/Prospero/PROX1 homeodomain protein in sensory-neuron function in C. elegans. Using glia expression profiling, we demonstrate that, unlike previously characterized cell fate roles, PROS-1 functions post-embryonically to control sense-organ glia-specific secretome expression. PROS-1 functions cell autonomously to regulate glial secretion and membrane structure, and non-cell autonomously to control the shape and function of the receptive endings of sensory neurons. Known glial genes controlling sensory-neuron function are PROS-1 targets, and we identify additional PROS-1-dependent genes required for neuron attributes. Drosophila Prospero and vertebrate PROX1 are expressed in post-mitotic sense-organ glia and astrocytes, suggesting conserved roles for this class of transcription factors.
巻・号 15(3)
ページ 550-562
公開日 2016-4-19
DOI 10.1016/j.celrep.2016.03.051
PII S2211-1247(16)30322-9
PMID 27068465
PMC PMC4838487
MeSH Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism* Cell Lineage Cell Shape* Cellular Microenvironment Embryo, Nonmammalian / cytology Embryo, Nonmammalian / metabolism Gene Deletion Gene Expression Regulation, Developmental Genes, Helminth Homeodomain Proteins / metabolism* Membrane Proteins / metabolism Mutation / genetics Neuroglia / metabolism* Proteome / metabolism* RNA Interference RNA, Messenger / genetics RNA, Messenger / metabolism Sensory Receptor Cells / cytology* Sensory Receptor Cells / metabolism*
IF 8.109
引用数 12
リソース情報
線虫 tm258