| RRC ID |
53282
|
| Author |
Dietrich N, Tan CH, Cubillas C, Earley BJ, Kornfeld K.
|
| Title |
Insights into zinc and cadmium biology in the nematode Caenorhabditis elegans.
|
| Journal |
Arch Biochem Biophys
|
| Abstract |
Zinc is an essential metal that is involved in a wide range of biological processes, and aberrant zinc homeostasis is implicated in multiple human diseases. Cadmium is chemically similar to zinc, but it is a nonessential environmental pollutant. Because zinc deficiency and excess are deleterious, animals require homeostatic mechanisms to maintain zinc levels in response to dietary fluctuations. The nematode Caenorhabditis elegans is emerging as a powerful model system to investigate zinc trafficking and homeostasis as well as cadmium toxicity. Here we review genetic and molecular studies that have combined to generate a picture of zinc homeostasis based on the transcriptional control of zinc transporters in intestinal cells. Furthermore, we summarize studies of cadmium toxicity that reveal intriguing parallels with zinc biology.
|
| Volume |
611
|
| Pages |
120-133
|
| Published |
2016-12-1
|
| DOI |
10.1016/j.abb.2016.05.021
|
| PII |
S0003-9861(16)30185-0
|
| PMID |
27261336
|
| MeSH |
Animals
Biological Transport
Cadmium / physiology*
Caenorhabditis elegans / physiology*
Cell Lineage
Culture Media
Diet
Dose-Response Relationship, Drug
Female
Green Fluorescent Proteins / chemistry
Homeostasis
Male
Models, Biological
Mutation
Phenotype
Spermatozoa / physiology
Vulva / physiology
Zinc / physiology*
|
| IF |
3.391
|
| Times Cited |
8
|
| Resource |
| C.elegans |
NA |
