Reference - Detail
| RRC ID | 53289 |
|---|---|
| Author | Zhou Q, Li H, Li H, Nakagawa A, Lin JL, Lee ES, Harry BL, Skeen-Gaar RR, Suehiro Y, William D, Mitani S, Yuan HS, Kang BH, Xue D. |
| Title | Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization. |
| Journal | Science |
| Abstract |
Mitochondria are inherited maternally in most animals, but the mechanisms of selective paternal mitochondrial elimination (PME) are unknown. While examining fertilization in Caenorhabditis elegans, we observed that paternal mitochondria rapidly lose their inner membrane integrity. CPS-6, a mitochondrial endonuclease G, serves as a paternal mitochondrial factor that is critical for PME. We found that CPS-6 relocates from the intermembrane space of paternal mitochondria to the matrix after fertilization to degrade mitochondrial DNA. It acts with maternal autophagy and proteasome machineries to promote PME. Loss of cps-6 delays breakdown of mitochondrial inner membranes, autophagosome enclosure of paternal mitochondria, and PME. Delayed removal of paternal mitochondria causes increased embryonic lethality, demonstrating that PME is important for normal animal development. Thus, CPS-6 functions as a paternal mitochondrial degradation factor during animal development. |
| Volume | 353(6297) |
| Pages | 394-9 |
| Published | 2016-7-22 |
| DOI | 10.1126/science.aaf4777 |
| PII | science.aaf4777 |
| PMID | 27338704 |
| PMC | PMC5469823 |
| MeSH | Animals Autophagy Caenorhabditis elegans / embryology* Caenorhabditis elegans / enzymology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* DNA, Mitochondrial / metabolism* Embryo, Nonmammalian / cytology Embryo, Nonmammalian / enzymology Endodeoxyribonucleases / genetics Endodeoxyribonucleases / metabolism* Fertilization* Male Mitochondria / enzymology* Mitochondrial Membranes / metabolism Mitochondrial Proteins / genetics Mitochondrial Proteins / metabolism* Proteasome Endopeptidase Complex / metabolism Spermatozoa / enzymology Spermatozoa / ultrastructure |
| IF | 41.846 |
| Times Cited | 64 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 378 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm3222 tm2595 |