論文 - 詳細
| RRC ID | 53302 |
|---|---|
| 著者 | Cook DE, Zdraljevic S, Tanny RE, Seo B, Riccardi DD, Noble LM, Rockman MV, Alkema MJ, Braendle C, Kammenga JE, Wang J, Kruglyak L, Félix MA, Lee J, Andersen EC. |
| タイトル | The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. |
| ジャーナル | Genetics |
| Abstract |
Telomeres are involved in the maintenance of chromosomes and the prevention of genome instability. Despite this central importance, significant variation in telomere length has been observed in a variety of organisms. The genetic determinants of telomere-length variation and their effects on organismal fitness are largely unexplored. Here, we describe natural variation in telomere length across the Caenorhabditis elegans species. We identify a large-effect variant that contributes to differences in telomere length. The variant alters the conserved oligonucleotide/oligosaccharide-binding fold of protection of telomeres 2 (POT-2), a homolog of a human telomere-capping shelterin complex subunit. Mutations within this domain likely reduce the ability of POT-2 to bind telomeric DNA, thereby increasing telomere length. We find that telomere-length variation does not correlate with offspring production or longevity in C. elegans wild isolates, suggesting that naturally long telomeres play a limited role in modifying fitness phenotypes in C. elegans. |
| 巻・号 | 204(1) |
| ページ | 371-83 |
| 公開日 | 2016-9-1 |
| DOI | 10.1534/genetics.116.191148 |
| PII | genetics.116.191148 |
| PMID | 27449056 |
| PMC | PMC5012401 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism DNA / metabolism Genetic Variation Genome-Wide Association Study Longevity / genetics Mutation Sequence Analysis, DNA Telomere / genetics* Telomere / metabolism Telomere-Binding Proteins / metabolism |
| IF | 4.015 |
| 引用数 | 38 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 53 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1400 |