論文 - 詳細
| RRC ID | 53359 |
|---|---|
| 著者 | Viollet B, Foretz M. |
| タイトル | Animal Models to Study AMPK. |
| ジャーナル | Exp Suppl |
| Abstract |
AMPK is an evolutionary conserved energy sensor involved in the regulation of energy metabolism. Based on biochemical studies, AMPK has brought much of interest in recent years due to its potential impact on metabolic disorders. Suitable animal models are therefore essential to promote our understanding of the molecular and functional roles of AMPK but also to bring novel information for the development of novel therapeutic strategies. The organism systems include pig (Sus scrofa), mouse (Mus musculus), fly (Drosophila melanogaster), worm (Caenorhabditis elegans), and fish (Danio rerio) models. These animal models have provided reliable experimental evidence demonstrating the crucial role of AMPK in the regulation of metabolism but also of cell polarity, autophagy, and oxidative stress. In this chapter, we update the new development in the generation and application of animal models for the study of AMPK biology. We also discuss recent breakthroughs from studies in mice, flies, and worms showing how AMPK has a primary role in initiating or promoting pathological or beneficial impact on health. |
| 巻・号 | 107 |
| ページ | 441-469 |
| 公開日 | 2016-1-1 |
| DOI | 10.1007/978-3-319-43589-3_18 |
| PMID | 27812991 |
| MeSH | AMP-Activated Protein Kinases / genetics* AMP-Activated Protein Kinases / metabolism Animals Animals, Genetically Modified Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics* Conserved Sequence Drosophila melanogaster / enzymology Drosophila melanogaster / genetics* Energy Metabolism / genetics Gene Expression Regulation* Homeostasis Humans Mice Models, Animal Protein Multimerization Protein Subunits / genetics Protein Subunits / metabolism Signal Transduction / genetics* Swine Zebrafish / genetics* Zebrafish / metabolism |
| 引用数 | 2 |
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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