RRC ID 53362
Author Li G, Gong J, Lei H, Liu J, Xu XZ.
Title Promotion of behavior and neuronal function by reactive oxygen species in C. elegans.
Journal Nat Commun
Abstract Reactive oxygen species (ROS) are well known to elicit a plethora of detrimental effects on cellular functions by causing damages to proteins, lipids and nucleic acids. Neurons are particularly vulnerable to ROS, and nearly all forms of neurodegenerative diseases are associated with oxidative stress. Here, we report the surprising finding that exposing C. elegans to low doses of H2O2 promotes, rather than compromises, sensory behavior and the function of sensory neurons such as ASH. This beneficial effect of H2O2 is mediated by an evolutionarily conserved peroxiredoxin-p38/MAPK signaling cascade. We further show that p38/MAPK signals to AKT and the TRPV channel OSM-9, a sensory channel in ASH neurons. AKT phosphorylates OSM-9, and such phosphorylation is required for H2O2-induced potentiation of sensory behavior and ASH neuron function. Our results uncover a beneficial effect of ROS on neurons, revealing unexpected complexity of the action of oxidative stressors in the nervous system.
Volume 7
Pages 13234
Published 2016-11-8
DOI 10.1038/ncomms13234
PII ncomms13234
PMID 27824033
PMC PMC5105148
MeSH Animals Avoidance Learning / drug effects Behavior, Animal* Caenorhabditis elegans / drug effects Caenorhabditis elegans / enzymology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Hydrogen Peroxide / pharmacology MAP Kinase Signaling System / drug effects Mitogen-Activated Protein Kinases / metabolism Nerve Tissue Proteins / metabolism Neurons / physiology* Osmosis Peroxiredoxins / metabolism Phosphorylation / drug effects Phosphothreonine / metabolism Proto-Oncogene Proteins c-akt / metabolism Reactive Oxygen Species / metabolism* Sensation / drug effects TRPV Cation Channels / metabolism
IF 11.878
Times Cited 16
Resource
C.elegans tm3476 tm3859