RRC ID 53386
Author Feng G, Zhu Z, Li WJ, Lin Q, Chai Y, Dong MQ, Ou G.
Title Hippo kinases maintain polarity during directional cell migration in Caenorhabditis elegans.
Journal EMBO J.
Abstract phosphorylation impedes actin assembly in migrating cells. Intriguingly, Hippo kinases are excluded from the leading edge in wild-type cells, while MIG-2 loss induces uniform distribution of Hippo kinases. We provide evidence that Hippo kinases inhibit RhoG activity locally and are in turn restricted to the cell body by RhoG-mediated polarization. Therefore, we propose that the Hippo-RhoG feedback regulation maintains cell polarity during directional cell motility.
Volume 36(3)
Pages 334-345
Published 2017-2-1
DOI 10.15252/embj.201695734
PII embj.201695734
PMID 28011581
Resource
C.elegans tm1900 tm4081 tm1416