論文 - 詳細
| RRC ID | 5339 |
|---|---|
| 著者 | Tanaka S, Miura I, Yoshiki A, Kato Y, Yokoyama H, Shinogi A, Masuya H, Wakana S, Tamura M, Shiroishi T. |
| タイトル | Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament. |
| ジャーナル | Genomics |
| Abstract |
Two classical mouse hair coat mutations, Rex (Re) and Rex wavy coat (Re(wc)), are linked to the type I inner root sheath (IRS) keratin genes of chromosome 11. An N-ethyl-N-nitrosourea-induced mutation, M100573, also maps close to the type I IRS keratin genes. In this study, we demonstrate that Re and M100573 mice bear mutations in the type I IRS gene Krt25; Re(wc) mice bear an additional mutation in the type I IRS gene Krt27. These three mutations are located in the helix termination motif of the 2B alpha-helical rod domain of a type I IRS keratin protein. Immunohistological analysis revealed abnormal foam-like immunoreactivity with an antibody raised to type II IRS keratin K71 in the IRS of Re/+ mice. These results suggest that the helix termination motif is essential for the proper assembly of types I and II IRS keratin protein complexes and the formation of keratin intermediate filaments. |
| 巻・号 | 90(6) |
| ページ | 703-11 |
| 公開日 | 2007-12-1 |
| DOI | 10.1016/j.ygeno.2007.07.013 |
| PII | S0888-7543(07)00182-6 |
| PMID | 17920809 |
| MeSH | Amino Acid Motifs Amino Acid Sequence Animals Base Sequence DNA / genetics Genetic Linkage Hair / metabolism Hair / pathology Hair Follicle / metabolism Hair Follicle / pathology Immunohistochemistry Intermediate Filaments / chemistry Intermediate Filaments / metabolism Keratins, Hair-Specific / biosynthesis Keratins, Hair-Specific / chemistry* Keratins, Hair-Specific / genetics* Mice Mice, Mutant Strains Molecular Sequence Data Mutation* Phenotype Phylogeny Sequence Deletion Sequence Homology, Amino Acid |
| IF | 6.205 |
| 引用数 | 21 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | GSC0105 |