Reference - Detail
| RRC ID | 53441 |
|---|---|
| Author | Greer EL, Becker B, Latza C, Antebi A, Shi Y. |
| Title | Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. |
| Journal | Cell Res |
| Abstract |
Complex organismal properties such as longevity can be transmitted across generations by non-genetic factors. Here we demonstrate that deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase, spr-5, causes a trans-generational increase in lifespan. We identify a chromatin-modifying network, which regulates this lifespan extension. We further show that this trans-generational lifespan extension is dependent on a hormonal signaling pathway involving the steroid dafachronic acid, an activator of the nuclear receptor DAF-12. These findings suggest that loss of the demethylase SPR-5 causes H3K4me2 mis-regulation and activation of a known lifespan-regulating signaling pathway, leading to trans-generational lifespan extension. |
| Volume | 26(2) |
| Pages | 229-38 |
| Published | 2016-2-1 |
| DOI | 10.1038/cr.2015.148 |
| PII | cr2015148 |
| PMID | 26691751 |
| PMC | PMC4746603 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Cholestenes / metabolism Chromatin / genetics Histone Demethylases / genetics* Histones / genetics Longevity / genetics* Methylation Mutation / genetics* Signal Transduction / genetics |
| IF | 20.507 |
| Times Cited | 25 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 8 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2966 tm1860 |