論文 - 詳細
| RRC ID | 53514 |
|---|---|
| 著者 | Colella E, Li S, Roy R. |
| タイトル | Developmental and Cell Cycle Quiescence Is Mediated by the Nuclear Hormone Receptor Coregulator DIN-1S in the Caenorhabditis elegans Dauer Larva. |
| ジャーナル | Genetics |
| Abstract |
When faced with suboptimal growth conditions, Caenorhabditis elegans larvae can enter a diapause-like stage called "dauer" that is specialized for dispersal and survival. The decision to form a dauer larva is controlled by three parallel signaling pathways, whereby a compromise of TGFβ, cyclic guanosine monophosphate, or insulin/IGF-like signaling (ILS) results in dauer formation. Signals from these pathways converge on DAF-12, a nuclear hormone receptor that triggers the changes required to initiate dauer formation. DAF-12 is related to the vitamin D, liver-X, and androstane receptors, and like these human receptors, it responds to lipophilic hormone ligands. When bound to its ligand, DAF-12 acquires transcriptional activity that directs reproductive development, while unliganded DAF-12 forms a dauer-specifying complex with its interacting protein DIN-1S to regulate the transcription of genes required for dauer development. We report here that din-1S is required in parallel to par-4/LKB1 signaling within the gonad to establish cell cycle quiescence during the onset of the dauer stage. We show that din-1S is important for postdauer reproduction when ILS is impaired and is necessary for long-term dauer survival in response to reduced ILS. Our work uncovers several previously uncharacterized functions of DIN-1S in executing and maintaining many of the cellular and physiological processes required for appropriate dauer arrest, while also shedding light on the coordination of nuclear hormone signaling, the LKB1/AMPK signaling cascade, and ILS/TGFβ in the control of cell cycle quiescence and tissue growth: a key feature that is often misregulated in a number of hormone-dependent cancers. |
| 巻・号 | 203(4) |
| ページ | 1763-76 |
| 公開日 | 2016-8-1 |
| DOI | 10.1534/genetics.116.191858 |
| PII | genetics.116.191858 |
| PMID | 27260305 |
| PMC | PMC4981276 |
| MeSH | Androstanes / metabolism Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / genetics* Cell Cycle / genetics Gonads / growth & development Gonads / metabolism Hormones / genetics Hormones / metabolism Humans Insulin / genetics Larva / genetics Larva / growth & development Metamorphosis, Biological / genetics* Protein Serine-Threonine Kinases / genetics* Receptors, Cytoplasmic and Nuclear / genetics* Signal Transduction / genetics Transcription Factors / genetics* Transforming Growth Factor beta / genetics* |
| IF | 4.015 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1944 |