RRC ID 53516
Author Desjardins D, Cacho-Valadez B, Liu JL, Wang Y, Yee C, Bernard K, Khaki A, Breton L, Hekimi S.
Title Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans.
Journal Aging Cell
Abstract Reactive oxygen species (ROS) are potentially toxic, but they are also signaling molecules that modulate aging. Recent observations that ROS can promote longevity have to be reconciled with the numerous claims about the benefits of antioxidants on lifespan. Here, three antioxidants [N-acetylcysteine (NAC), vitamin C, and resveratrol (RSV)] were tested on Caenorhabditis elegans mutants that alter drug uptake, mitochondrial function, and ROS metabolism. We observed that like pro-oxidants, antioxidants can both lengthen and shorten lifespan, dependent on concentration, genotypes, and conditions. The effects of antioxidants thus reveal an inverted U-shaped dose-response relationship between ROS levels and lifespan. In addition, we observed that RSV can act additively to both NAC and paraquat, to dramatically increase lifespan. This suggests that the effect of compounds that modulate ROS levels can be additive when their loci of action or mechanisms of action are sufficiently distinct.
Volume 16(1)
Pages 104-112
Published 2017-2-1
DOI 10.1111/acel.12528
PMID 27683245
PMC PMC5242296
MeSH Acetylcysteine / pharmacology Aging / drug effects Aging / physiology* Animals Antioxidants / pharmacology* Ascorbic Acid / pharmacology Caenorhabditis elegans / drug effects Caenorhabditis elegans / physiology* Longevity / drug effects Mitochondria / drug effects Mitochondria / metabolism Models, Biological Mutation / genetics Oxidative Stress / drug effects Paraquat / pharmacology Reactive Oxygen Species / metabolism* Resveratrol Stilbenes / pharmacology Superoxide Dismutase / metabolism
IF 7.346
Times Cited 26
C.elegans tm783 tm760 tm1246