論文 - 詳細
| RRC ID | 53655 |
|---|---|
| 著者 | Barton NR, Burgard AP, Burk MJ, Crater JS, Osterhout RE, Pharkya P, Steer BA, Sun J, Trawick JD, Van Dien SJ, Yang TH, Yim H. |
| タイトル | An integrated biotechnology platform for developing sustainable chemical processes. |
| ジャーナル | J Ind Microbiol Biotechnol |
| Abstract |
Genomatica has established an integrated computational/experimental metabolic engineering platform to design, create, and optimize novel high performance organisms and bioprocesses. Here we present our platform and its use to develop E. coli strains for production of the industrial chemical 1,4-butanediol (BDO) from sugars. A series of examples are given to demonstrate how a rational approach to strain engineering, including carefully designed diagnostic experiments, provided critical insights about pathway bottlenecks, byproducts, expression balancing, and commercial robustness, leading to a superior BDO production strain and process. |
| 巻・号 | 42(3) |
| ページ | 349-60 |
| 公開日 | 2015-3-1 |
| DOI | 10.1007/s10295-014-1541-1 |
| PMID | 25416472 |
| MeSH | Biotechnology / methods* Butylene Glycols / metabolism Carbon Isotopes Escherichia coli / enzymology Escherichia coli / genetics Escherichia coli / metabolism Fermentation Green Chemistry Technology* Metabolic Engineering Metabolic Networks and Pathways / genetics Systems Biology |
| IF | 3.103 |
| 引用数 | 28 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(大腸菌) | |