論文 - 詳細
| RRC ID | 53949 |
|---|---|
| 著者 | Fassnacht C, Tocchini C, Kumari P, Gaidatzis D, Stadler MB, Ciosk R. |
| タイトル | The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans. |
| ジャーナル | PLoS Genet |
| Abstract |
Endogenous RNAi (endoRNAi) is a conserved mechanism for fine-tuning gene expression. In the nematode Caenorhabditis elegans, several endoRNAi pathways are required for the successful development of reproductive cells. The CSR-1 endoRNAi pathway promotes germ cell development, primarily by facilitating the expression of germline genes. In this study, we report a novel function for the CSR-1 pathway in preventing premature activation of embryonic transcription in the developing oocytes, which is accompanied by a general Pol II activation. This CSR-1 function requires its RNase activity, suggesting that, by controlling the levels of maternal mRNAs, CSR-1-dependent endoRNAi contributes to an orderly reprogramming of transcription during the oocyte-to-embryo transition. |
| 巻・号 | 14(3) |
| ページ | e1007252 |
| 公開日 | 2018-3-1 |
| DOI | 10.1371/journal.pgen.1007252 |
| PII | PGENETICS-D-17-01790 |
| PMID | 29579041 |
| PMC | PMC5886687 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Embryo, Nonmammalian Female Gene Expression Regulation, Developmental Mutation Oocytes / physiology* RNA Interference* RNA Polymerase II / genetics RNA Polymerase II / metabolism Transcription Factors / genetics |
| IF | 5.175 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm892 tm1217 |