論文 - 詳細
| RRC ID | 54114 |
|---|---|
| 著者 | Horie M, Miyashita N, Mattsson JSM, Mikami Y, Sandelin M, Brunnström H, Micke P, Nagase T, Saito A. |
| タイトル | An integrative transcriptome analysis reveals a functional role for thyroid transcription factor-1 in small cell lung cancer. |
| ジャーナル | J Pathol |
| Abstract |
Small cell lung cancer (SCLC) is a neuroendocrine tumour that exhibits rapid growth and metastatic spread. Although SCLC represents a prototypically undifferentiated cancer type, thyroid transcription factor-1 (TTF-1, gene symbol NKX2-1), a master regulator for pulmonary epithelial cell differentiation and lung morphogenesis, is strongly upregulated in this aggressive cancer type. The aim of this study was to evaluate a functional role for TTF-1 in SCLC. We demonstrated that achaete-scute complex homolog 1 (ASCL1), an essential transcription factor for neuroendocrine differentiation, positively regulated TTF-1 in SCLC cell lines. Subsequently, we described genes and microRNAs (miRNAs) that were possibly controlled by TTF-1 and identified nuclear factor IB (NFIB), a recently characterised driver of SCLC progression, as a transcriptional target of TTF-1. Our findings shine light on a regulatory axis in SCLC consisting of ASCL1/TTF-1/NFIB that potentially contributes to the tumourigenesis of SCLC. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
| 巻・号 | 246(2) |
| ページ | 154-165 |
| 公開日 | 2018-10-1 |
| DOI | 10.1002/path.5109 |
| PMID | 29876935 |
| MeSH | Basic Helix-Loop-Helix Transcription Factors / genetics Basic Helix-Loop-Helix Transcription Factors / metabolism Cell Differentiation Cell Line, Tumor Databases, Genetic Female Gene Expression Profiling / methods* Gene Expression Regulation, Neoplastic Humans Lung Neoplasms / genetics* Lung Neoplasms / metabolism Lung Neoplasms / pathology Male MicroRNAs / genetics MicroRNAs / metabolism NFI Transcription Factors / genetics NFI Transcription Factors / metabolism Prognosis Signal Transduction Small Cell Lung Carcinoma / genetics* Small Cell Lung Carcinoma / metabolism Small Cell Lung Carcinoma / pathology Thyroid Nuclear Factor 1 / genetics* Thyroid Nuclear Factor 1 / metabolism* Transcription, Genetic Transcriptome* |
| IF | 5.942 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Lu-134-A(RCB0466) Lu-134-B(RCB0467) Lu-139(RCB0469) |