RRC ID 54341
著者 Mohammad A, Vanden Broek K, Wang C, Daryabeigi A, Jantsch V, Hansen D, Schedl T.
タイトル Initiation of Meiotic Development Is Controlled by Three Post-transcriptional Pathways in Caenorhabditis elegans.
ジャーナル Genetics
Abstract A major event in germline development is the transition from stem/progenitor cells to entry into meiosis and gametogenesis. This transition requires downregulation of mitotic cell cycle activity and upregulation of processes associated with meiosis. We identify the Caenorhabditis elegans SCFPROM-1 E3 ubiquitin-ligase complex as functioning to downregulate mitotic cell cycle protein levels including cyclin E, WAPL-1, and KNL-2 at meiotic entry and, independently, promoting homologous chromosome pairing as a positive regulator of the CHK-2 kinase. SCFPROM-1 is thus a novel regulator of meiotic entry, coordinating downregulation of mitotic cell cycle proteins and promoting homolog pairing. We further show that SCFPROM-1 functions redundantly, in parallel to the previously described GLD-1 and GLD-2 meiotic entry pathways, downstream of and inhibited by GLP-1 Notch signaling, which specifies the stem cell fate. Accordingly, C. elegans employs three post-transcriptional pathways, SCFPROM-1-mediated protein degradation, GLD-1-mediated translational repression, and GLD-2-mediated translational activation, to control and coordinate the initiation of meiotic development.
巻・号 209(4)
ページ 1197-1224
公開日 2018-8-1
DOI 10.1534/genetics.118.300985
PII genetics.118.300985
PMID 29941619
PMC PMC6063227
MeSH Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Cell Cycle Proteins / genetics Checkpoint Kinase 2 / genetics Drosophila Proteins / genetics F-Box Proteins / genetics Gametogenesis Gene Expression Regulation Gene Regulatory Networks* Meiosis* Polynucleotide Adenylyltransferase / genetics Protein Biosynthesis Proteolysis Receptors, Notch / genetics Signal Transduction*
IF 4.015
引用数 8
リソース情報
線虫 tm814 tm3538