RRC ID 54362
Author Hashimoto O, Funaba M, Sekiyama K, Doi S, Shindo D, Satoh R, Itoi H, Oiwa H, Morita M, Suzuki C, Sugiyama M, Yamakawa N, Takada H, Matsumura S, Inoue K, Oyadomari S, Sugino H, Kurisaki A.
Title Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine.
Journal Cell Rep
Abstract Brown adipocyte activation or beige adipocyte emergence in white adipose tissue (WAT) increases energy expenditure, leading to a reduction in body fat mass and improved glucose metabolism. We found that activin E functions as a hepatokine that enhances thermogenesis in response to cold exposure through beige adipocyte emergence in inguinal WAT (ingWAT). Hepatic activin E overexpression activated thermogenesis through Ucp1 upregulation in ingWAT and other adipose tissues including interscapular brown adipose tissue and mesenteric WAT. Hepatic activin E-transgenic mice exhibited improved insulin sensitivity. Inhibin βE gene silencing inhibited cold-induced Ucp1 induction in ingWAT. Furthermore, in vitro experiments suggested that activin E directly stimulated expression of Ucp1 and Fgf21, which was mediated by transforming growth factor-β or activin type I receptors. We uncovered a function of activin E to stimulate energy expenditure through brown and beige adipocyte activation, suggesting a possible preventive or therapeutic target for obesity.
Volume 25(5)
Pages 1193-1203
Published 2018-10-30
DOI 10.1016/j.celrep.2018.10.008
PII S2211-1247(18)31571-7
PMID 30380411
MeSH Activin Receptors, Type I / metabolism Activins / metabolism* Adipocytes, Beige / metabolism Adipocytes, Brown / metabolism Adipose Tissue, Brown / metabolism* Adipose Tissue, White / metabolism* Animals Body Weight Cell Differentiation Cold Temperature Energy Metabolism* Fibroblast Growth Factors / metabolism Glucose / metabolism HEK293 Cells Homeostasis* Humans Inhibin-beta Subunits / metabolism* Insulin Resistance Lipid Metabolism Liver / metabolism Male Mice, Inbred C57BL Mice, Knockout Thermogenesis Transforming Growth Factor beta / metabolism
IF 8.109
Times Cited 10
DNA material pCALNL5 (RDB01862)
Human and Animal Cells 293(RCB1637)