論文 - 詳細
| RRC ID | 54560 |
|---|---|
| 著者 | Yabuki Y, Ikeda A, Araki M, Kajiwara K, Mizuta K, Funato K. |
| タイトル | Sphingolipid/Pkh1/2-TORC1/Sch9 Signaling Regulates Ribosome Biogenesis in Tunicamycin-Induced Stress Response in Yeast. |
| ジャーナル | Genetics |
| Abstract |
Reduced ribosome biogenesis in response to environmental conditions is a key feature of cell adaptation to stress. For example, ribosomal genes are transcriptionally repressed when cells are exposed to tunicamycin, a protein glycosylation inhibitor that induces endoplasmic reticulum stress and blocks vesicular trafficking in the secretory pathway. Here, we describe a novel regulatory model, in which tunicamycin-mediated stress induces the accumulation of long-chain sphingoid bases and subsequent activation of Pkh1/2 signaling, which leads to decreased expression of ribosomal protein genes via the downstream effectors Pkc1 and Sch9. Target of rapamycin complex 1 (TORC1), an upstream activator of Sch9, is also required. This pathway links ribosome biogenesis to alterations in membrane lipid composition under tunicamycin-induced stress conditions. Our results suggest that sphingolipid/Pkh1/2-TORC1/Sch9 signaling is an important determinant for adaptation to tunicamycin-induced stress. |
| 巻・号 | 212(1) |
| ページ | 175-186 |
| 公開日 | 2019-5-1 |
| DOI | 10.1534/genetics.118.301874 |
| PII | genetics.118.301874 |
| PMID | 30824472 |
| PMC | PMC6499531 |
| MeSH | 3-Phosphoinositide-Dependent Protein Kinases / metabolism Endoplasmic Reticulum Stress / drug effects* Gene Expression Regulation, Fungal Protein Serine-Threonine Kinases / metabolism Ribosomes / metabolism* Saccharomyces cerevisiae / drug effects Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae / metabolism* Saccharomyces cerevisiae Proteins / metabolism Signal Transduction* Sphingolipids / metabolism Transcription Factors / metabolism Tunicamycin / pharmacology* Tunicamycin / toxicity |
| IF | 3.564 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | |