論文 - 詳細
| RRC ID | 54566 |
|---|---|
| 著者 | Seong KH, Akimaru H, Dai P, Nomura T, Okada M, Ishii S. |
| タイトル | Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal. |
| ジャーナル | PLoS One |
| Abstract |
Hedgehog (Hh) signalling plays an important role in various developmental processes by activating the Cubitus interruptus (Ci)/Glioblastoma (Gli) family of transcription factors. In the process of proper pattern formation, Ci activity is regulated by multiple mechanisms, including processing, trafficking, and degradation. However, it remains elusive how Ci distinctly recognizes the strong and moderate Hh signals. Roadkill (Rdx) induces Ci degradation in the anterior region of the Drosophila wing disc. Here, we report that Rdx inhibited Ci activity by two different mechanisms. In the region abutting the anterior/posterior boundary, which receives strong Hh signal, Rdx inhibited the nuclear import of Ci by releasing importin α3 from Ci. In this region, Rdx negatively regulated the expression of transcription factor Knot/Collier. In farther anterior regions receiving moderate levels of Hh signal, Rdx induced Ci degradation, as reported previously. Thus, two different mechanisms by which Rdx negatively regulates Ci may play an important role in the fine-tuning of Hh responses. |
| 巻・号 | 5(12) |
| ページ | e15365 |
| 公開日 | 2010-12-15 |
| DOI | 10.1371/journal.pone.0015365 |
| PMID | 21179535 |
| PMC | PMC3002282 |
| MeSH | Active Transport, Cell Nucleus Animals Crosses, Genetic DNA-Binding Proteins / metabolism* Drosophila Proteins / metabolism* Drosophila melanogaster Genotype Hedgehog Proteins / metabolism* Intracellular Signaling Peptides and Proteins / metabolism* Models, Genetic Mutation Plasmids / metabolism Protein Isoforms RNA Interference Transcription Factors / metabolism* Two-Hybrid System Techniques |
| IF | 2.776 |
| 引用数 | 12 |
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| 各媒体での言及数の合計 | 0 |
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