論文 - 詳細
| RRC ID | 54613 |
|---|---|
| 著者 | Ravikumar R, Kalbfuß N, Gendre D, Steiner A, Altmann M, Altmann S, Rybak K, Edelmann H, Stephan F, Lampe M, Facher E, Wanner G, Falter-Braun P, Bhalerao RP, Assaad FF. |
| タイトル | Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis. |
| ジャーナル | Development |
| Abstract |
The trans-Golgi-network (TGN) has essential housekeeping functions in secretion, endocytosis and protein sorting, but also more specialized functions in plant development. How the robustness of basal TGN function is ensured while specialized functions are differentially regulated is poorly understood. Here, we investigate two key regulators of TGN structure and function, ECHIDNA and the Transport Protein Particle II (TRAPPII) tethering complex. An analysis of physical, network and genetic interactions suggests that two network communities are implicated in TGN function and that ECHIDNA and TRAPPII belong to distinct yet overlapping pathways. Whereas ECHIDNA and TRAPPII colocalized at the TGN in interphase cells, their localization diverged in dividing cells. Moreover, ECHIDNA and TRAPPII localization patterns were mutually independent. TGN structure, endocytosis and sorting decisions were differentially impacted in echidna and trappii mutants. Our analyses point to a partitioning of specialized TGN functions, with ECHIDNA being required for cell elongation and TRAPPII for cytokinesis. Two independent pathways able to compensate for each other might contribute to the robustness of TGN housekeeping functions and to the responsiveness and fine tuning of its specialized functions. |
| 巻・号 | 145(21) |
| 公開日 | 2018-11-7 |
| DOI | 10.1242/dev.169201 |
| PII | 145/21/dev169201 |
| PMID | 30404777 |
| MeSH | Arabidopsis / cytology Arabidopsis / embryology Arabidopsis / metabolism* Arabidopsis / ultrastructure Arabidopsis Proteins / genetics Arabidopsis Proteins / metabolism Biomarkers / metabolism Cell Membrane / metabolism Cytokinesis Endocytosis Epistasis, Genetic Green Fluorescent Proteins / metabolism Hypocotyl / metabolism Hypocotyl / ultrastructure Mutation / genetics Plant Roots / metabolism Protein Transport Signal Transduction* trans-Golgi Network / metabolism* trans-Golgi Network / ultrastructure |
| IF | 5.763 |
| 引用数 | 9 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| シロイヌナズナ / 植物培養細胞・遺伝子 | pda |