Reference - Detail
| RRC ID | 54794 |
|---|---|
| Author | Nishioka T, Tada H, Ibaragi S, Chen C, Sasano T. |
| Title | Nicotine exposure induces the proliferation of oral cancer cells through the α7 subunit of the nicotinic acetylcholine receptor. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Oral cancer and smoking are closely related, because the oral cavity, which is the route of ingestion of tobacco smoke, is in direct contact with the oral mucosa. Nicotine, one of the components of tobacco, can diffuse rapidly to the central nervous system and is responsible for tobacco addiction. Nicotine is present in high concentrations in the bloodstream of smokers; while the addictive effects of this alkaloid have extensively been studied, its effect on tumorigenesis is not clear yet. Therefore, in this study, we examined the effect of nicotine on cell proliferation and the signaling pathways it activates. The human oral squamous cell carcinoma cell line HSC-2 was used as a model system. We demonstrated the correlation between nicotine and epidermal growth factor receptor (EGFR) signaling. Nicotine treatment induced HSC-2 cell proliferation and migration and the phosphorylation of EGFR. Furthermore, nicotine treatment activated the EGFR downstream effectors phosphatidylinositol-3 kinase/AKT and p44/42 mitogen-activated protein kinases (ERK), which, in turn, promoted cell proliferation. Overall, our study suggests that nicotine promotes cell growth and migration through epidermal growth factor (EGF) signaling and plays an important role in oral cancer progression. |
| Volume | 509(2) |
| Pages | 514-520 |
| Published | 2019-2-5 |
| DOI | 10.1016/j.bbrc.2018.12.154 |
| PII | S0006-291X(18)32823-7 |
| PMID | 30598264 |
| MeSH | Carcinoma, Squamous Cell / etiology Carcinoma, Squamous Cell / metabolism Carcinoma, Squamous Cell / pathology* Cell Line, Tumor Cell Movement / drug effects Cell Proliferation / drug effects ErbB Receptors / metabolism Humans MAP Kinase Signaling System / drug effects Mouth Neoplasms / etiology Mouth Neoplasms / metabolism Mouth Neoplasms / pathology* Nicotine / adverse effects* Proto-Oncogene Proteins c-akt / metabolism Signal Transduction / drug effects Tobacco Smoking / adverse effects Tobacco Smoking / metabolism Tobacco Smoking / pathology alpha7 Nicotinic Acetylcholine Receptor / metabolism* |
| IF | 2.705 |
| Times Cited | 2 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| Human and Animal Cells | HSC-2(RCB1945) |